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The study explores how the mechanosensitive ion channel Piezo1 regulates group 2 innate lymphoid cells (ILC2s) and their role in airway hyperreactivity (AHR) in allergic asthma. It shows that Piezo1 acts as a negative regulator of ILC2 function, with its genetic deletion leading to increased ILC2 activity and worsened AHR. Agonist mediated Piezo1 activation suppressed ILC2-driven inflammation suggesting that Piezo1 agonists could have therapeutic potential for treating allergic asthma.
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