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Ion channels and transporters in immunity are increasingly recognized as critical regulators of immune cell function. Ion channels and transporters (ICTs) are well known for their essential roles in organs such as the kidney, heart, and nervous system, where they control processes like membrane potential, electrical excitability, and secretion through the regulated movement of ions including Ca²⁺, K⁺, and Cl⁻. However, their importance in the immune system has historically been underappreciated. Because immune cells are considered non-excitable, they have often been overlooked by researchers in ion channel physiology, and ICTs are not typically included in the standard immunology curriculum, despite their fundamental role in immune cell activation, signaling, proliferation, and differentiation. This disconnect driven in part by technological and conceptual divides between immunology and ion channel biology has slowed progress in the field and contributed to the limited development of FDA-approved therapies targeting ICTs for immunological disorders. The significance of ICTs in immunity is clearly demonstrated by genetic mutations in genes encoding key channels and transporters such as ORAI1, STIM1, LRRC8A, and ZIP7, which lead to channelopathies characterized by impaired immune cell development and function. In particular, pathways like store-operated calcium entry (SOCE) play a central role in regulating intracellular signaling and shaping immune responses. With the rapid advancement of new technologies, including improved animal models, structural biology, and high-resolution imaging, our understanding of ICTs in the immune system is expanding quickly. These advances are uncovering new mechanisms and highlighting the therapeutic potential of targeting ion channels in diseases such as asthma, inflammation, and autoimmunity. By bridging the gap between disciplines and fostering collaboration, initiatives like ImmunoChannels aim to accelerate research and drive innovation in this emerging and highly relevant field.